GXL · Paperclip

Discover what’s hidden in existing science.

GXL builds the knowledge layer AI agents need to reliably search and connect scientific evidence at scale. Our AI-native indexing makes it possible for agents to quickly and reliably identify therapeutic hypotheses worth testing.

More of what science already knows, for the questions that come next.

  • All sources 385M+
  • Articles 211M+
  • Regulatory & trials 1.3M+
  • Biological databases 3.8M+
  • Patents 170M+
Why GXL

The next therapeutic lead may be hiding in plain sight. Your AI agents need a structured way to find it.

The scientific record is distributed across generations of papers, databases, clinical trials, regulatory records, figures, supplements, and accumulated research. WIth AI, agents can search and synthesize this data at a scale no one has seen before. AI helps us draw connections we couldn’t see, to develop new therapies for patients.

GXL gives AI agents one structured environment to connect scientific findings across sources and preserve the path back to the evidence.

Faster, more reliable investigation can make more therapeutic ideas feasible to pursue, and reduce risk across the development lifecycle.

  • Broader evidence

    Search across papers, patents, trials, regulatory records, and biological databases in a single investigation.

  • Faster investigation

    Explore multiple evidence threads in parallel without losing the path back to the source.

  • Lower compute cost

    Persistent indexed context and agent-native queries cut token spend per task and across repeated runs

  • Source level traceability

    Every synthesized result can preserve the route back to the underlying evidence.

GXL's Paperclip is is trusted by

  • 12 of the top 20 pharma companies
  • 20 leading biotechs
  • 100+ universities and research institutes
GXL Results

In one FDA analysis, an AI agent with GXL’s Paperclip flagged 18 of 21 drugs—2.1× faster at 47% lower cost.

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Evaluated on scientific work

GXL Evaluation

Paperclip performance on bioRxiv questions

Average across 140 real research questions: deep paper Q&A (50), experiment novelty checks (50) and multi-paper synthesis (40).

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Accuracy / Completeness
  • 91%
  • 57%
  • 31%
Avg time
  • 14.9m
  • 4.5m
  • 1.9m
Avg cost
  • $0.37
  • $1.32
  • $1.00

  • Paperclip Chat
  • Claude Code + bioRxiv MCP
  • FutureHouse Edison
Protein Data

Paperclip performance vs other agents across 20 protein questions

20 questions spanning target characterization, structural profiling, and druggability assessment

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Completion
  • 100%
  • 80%
  • 85%
  • 55%
  • 40%
Accuracy
  • 97.1%
  • 78.3%
  • 81.9%
  • 53.8%
  • 39.5%
Avg time
  • 1.7m
  • 6.5m
  • 12m
  • 9.1m
  • 13m
Avg cost
  • $0.22
  • N/A
  • N/A
  • $1.24
  • $1.93

  • Paperclip
  • Phylo
  • Claude Science
  • MCP
  • Web Search
FDA Analysis

Paperclip performance on FDA analysis

Replicating one published FDA analysis: 18 of 21 drugs flagged, 2.1× faster and 47% lower cost with Paperclip.

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Drugs from original paper flagged
  • 86%
  • 71%
Median cost per drug
  • $0.45
  • $0.85
Median wall time per drug
  • 65 s
  • 136 s

  • With Paperclip
  • Without Paperclip
Paperclip

Generate and analyze novel datasets to form new hypotheses and de-risk development.

  • Therapeutic research

    Examine targets, mechanisms, and disease biology for leads worth testing.

  • Risk assessment

    Check prior trials, patents, and regulatory findings before the next decision.

  • Translational science

    Connect preclinical findings with clinical and biological context.

  • Clinical development

    Follow related mechanisms, programs, and patent activity across a therapeutic field.

  • Competitive intelligence

    Follow related mechanisms, programs, and patent activity across a therapeutic field.

  • Drug repurposing

    Investigate new uses for known compounds against existing evidence.

Paperclip by GXL

More of what science knows, available for the questions that come next.

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